The Buffalo Bills will be without another offensive weapon.

Sammy Watkins will not play against the Titans on Sunday because of a calf injury.

Running backs LeSean McCoy and Karlos Williams have already been ruled out for the Bills.

Watkins exited early in Week 3 with the injury and despite optimism from coach Rex Ryan that the wideout would get back on the field against the Tennessee Titans, the Bills will try to get back above .500 without their most dynamic threat.

Sans Watkins, the Bills‘ offense was constricted against the New York Giants last week. Without their stud pass-catcher to garner extra defensive attention, Percy Harvin was less explosive and quarterback Tyrod Taylor looked to tight end Charles Clay over the middle more often.

With a banged up offense, Ryan’s defense will need to discombobulate rookie quarterback Marcus Mariota and put the offense in optimal situations to get the road victory.

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